Everything you need to know about Oleoylethanolamide
What’s the Oleoylethanolamide?
Oleoylethanolamide (OEA) is an endogenous regulator of appetite which suppresses food intake. It is in the class of molecules known as acylethanolamides, which are ethanolamide molecules based off of fatty acids and usually related to the arachidonic acid derivative and cannabinoid known as anandamide. Also in this category of molecules is the endogenous sleep regulator oleamide, which is structurally similar to anandamide and OEA.
OEA is thought to be an endogenous regulator of satiety. Basal concentrations of OEA in the intestines (where it initially acts) without supplementation are in the range of 300nM during daylight hours in rats when they are satiated, and this concentration is enough to fully saturate the receptor it acts upon (PPARα). At night time, when rats tend to increase food intake, its concentrations drop to levels that no longer saturate the receptor.
It is synthesized in vivo from fatty acids from cell membranes, and is released when feeding occurs.
The functionality of Oleoylethanolamide (oea)
OEA or Oleoylethanolamide is a drug that helps you to regulate weight, eating habits, and cholesterol. It is a natural metabolite. It regulates the fat of your body by increasing the metabolism of the fat that is present in your body. It works in a very interesting way.
As and when you take in food, this drug will send a signal to your brain asking you to stop eating or take any further food as your body has already taken enough food and need no more. Thereby, you will start feeling that you are filled up and hence you stop eating. So, gradually you keep on taking less quantity of food each time regularly. Thus, in the long run, you can able to reduce weight to a great extent.
Uses of Oleoylethanolamide (OEA)
Uses of OEA activates in a very strategic manner. Firstly, it increases the gap in time between one meal to the next meal. Secondly, it helps in reducing circadian fluctuations. Thirdly, it is controlled by the available nutrients.
The functional effects of OEA and its beneficiary factors were discovered just fifty years ago. There was no such thorough and structured research about OEA before the year 2001. It was the researchers from Spain who started to study about OEA, tested on the rats to find out the effects. The study stated that OEA has no adverse effect on the brains but can change the eating habits and has an effect on the hunger behaviorism.
The molecular formula is C2OH39NO2. The unique CAS number is 111-58-0. OEA is a combination of oleic acid and ethanolamine. In the presence of rich fat which is present on the upper part of the small intestine in our body is the place where the synthesis of these two components is mainly done. OEA is very similar and alike to endocannabinoid anandamide but rather even better.
The dosage of oleoylethanolamide (oea)
Dosage of OEA can be taken in two ways based upon the doctor’s advice:
OEA took without any other weight reduction supplement
If the OEA capsule is taken without any weight reduction supplement then you can intake 1 OEA capsule of 200mg.
OEA took with another weight reduction supplement
If the OEA capsule is taken along with another weight reduction supplement then you can intake 1 OEA capsule of 100 mg to 150 mg.
One must intake the OEA capsule thirty minutes before having meals. This will keep you more satiable while you are having the meal and thereby you will end up consuming less quantity of food.
Moreover, you can even increase or decrease the level of your daily dosage of OEA based upon the weight of your body. Suppose, a person who is weighing 150 lb takes in the OEA capsule of 100mg. But if a person weighs 250 lb, he can take in the OEA capsule of 180 mg.
The raw material supplier of Oleoylethanolamide (OEA)
One can purchase an OEA drug from a reputed and proficient drug store located nearby your dwelling place or can even buy it by ordering online. But one has to be very alert in this respect as all the suppliers of this drug might not be genuine.
So, always check the reputation and the proficiency of the online drug stores and for that, it is always advisable to go through the details of the reviews of the experienced purchasers. Be sure about the packaging of the product like whether it is properly sealed or not to avoid any type of contamination which can result in some dangerous issues in the health front.
Oleoylethanolamide (oea) in the form of powder
OEA in its original state is not found in the form of tablets or capsules. However, you can buy OEA powder in bulkin the market if required. This powder form is incorporated in the finished product by regularizing it to 15 % OEA or 50 % OEA oleic acid. The blueprint of Cima OEA is maintained between 90 % to 95 % especially among the purchasers of Europe and the United States.
Buy Oleoylethanolamide (OEA) powder in bulk
You can place an online order for bulk purchase of powder or can even buy from reputed local stores. Storage is pretty simple in the case of OEA powder. You need to store it at room temperature. But, it should not come in contact with the moisture or direct sun rays. So, you need to keep it tightly sealed in a cool and dry place.
STABILITY
Uses of OEAcan help you in many ways! For this reason, highly recommendable to everyone as it has no side effects. It can even induce a healthy lifestyle within your family making all of you grow and glow in shape, style, and with esteem and confidence. Keeping and maintaining your body in shape, especially for those who are a little bit obese, will not only make you feel happy but will also make others feel happy and proud too about you.
OEA will also help you to release out mental stress helping you to create a positive impression in others’ minds. Thus, instead of feeling upset and unhappy, it is high time to take an action and start using OEA and you will be extremely amazed to see its magical powers and you will feel healed and caressed.
References
(1).Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. The Journal of the American Medical Association. 2006; 295(7):761–775.
(3).Sarro-Ramirez A, Sanchez-Lopez D, Tejeda-Padron A, Frias C, Zaldivar-Rae J, Murillo-Rodriguez E. Brain molecules and appetite: the case of oleoylethanolamide. Central Nervous System Agents in Medicinal Chemistry. 2013;13(1):88–91.