Anandamide (ANA), also known as N-arachidonoylethanolamine (AEA), is a fatty acid neurotransmitter derived from the non-oxidative metabolism of eicosatetraenoic acid (arachidonic acid), an essential omega-6 fatty acid. The name is taken from the Sanskrit word ananda, which means "joy, bliss, delight", and amide. It is synthesized from N-arachidonoyl phosphatidylethanolamine by multiple pathways. It is degraded primarily by the fatty acid amide hydrolase (FAAH) enzyme, which converts anandamide into ethanolamine and arachidonic acid.
In recent years, Anandamide (AEA) has become more and more popular. People's demand for it is also increasing. In this article, we will explore why anandamide is so increasingly popular in recent years?
1. Imperative -- The importants of Anandamide
Anandamide’s ability to bind to CB1 and CB2 receptors can profoundly impact a host of physiological mechanisms, including appetite stimulation, mood fluctuation, pain management, and even fertility.
Activation and binding of anandamide to our cannabinoid receptors results from our body’s constant pursuit to achieve and maintain homeostasis. When our cells, organs, and systems begin to shift away from their balance points, our endocannabinoid system kicks in.
Our bodies shift to balance themselves into the “Goldilocks Zone” (or homeostasis), where the conditions of our systems need to be just right in order to maintain optimal cellular performance.
One way that anandamide contributes to this homeostatic regulation is by binding to CB receptors and encouraging the development of nerve cells in the brain. This process is known as neurogenesis, which is important because the formation of new nerve cells in the brain is imperative for functions such as memory and learning.
1. Legality -- Comparison with CBD and THC
Before answering this question that why anandamide is so increasingly popular in recent years?, we need to mention cannabis, THC & CBD (Cannabidiol) first. Cannabis, also known as marijuana, is a flowering plant, and people use it as a party drug or smoke it to create a “high” or “stoned” feeling.
The active ingredient in cannabis that makes you high is THC, with the full name as delta 9-Tetrahydrocannabinol. When people smoke marijuana, the tetrahydrocannabinol in cannabis stimulates the cannabis receptor, making people feel a sense of happiness and mental well-being.
Cannabis is illegal in many countries since too many people will be addicted to it. However, Uruguay is the first country to legalize cannabis in the year 2013. On Oct 17 of 2018, the Canadian government declared that cannabis become legal all over Canada.
In the United States, cannabis-related laws are evolving regularly. Technically, Hemp has been removed from the Controlled Substances Act, but the Drug Enforcement Administration (DEA) and Food and Drug Administration (FDA) still classify CBD as a Schedule I drug. The cannabis may need to be prescribed by a licensed physician.
In states where cannabis is legal for recreational or medical purposes, you should be able to buy CBD. Before you try to buy products with CBD or THC, it’s important to research your state’s laws.
Since cannabis is forbidden in most countries, supplements, foods, beverages or cosmetics containing THC is illegal. In this sense, anandamide is the future.
1. Uses -- Good for your body
Scientific evidence suggests anandamide may be good for anti-anxiety, mental health, memory processing, appetite control, pain relief, neuroprotection, and more. Discussed below are some of the most popular anandamide uses;
⦁ Anandamide is used to improve mental health
People name Anandamide “
bliss molecule” because AEA is able to make you feel happy. Anandamide bliss molecule works to improve people’s mental health. Converging evidence suggests that the endocannabinoid system is an important constituent of neuronal substrates involved in brain reward processes and emotional responses to stress.
Another 2014 study documented in Translational Psychiatry journal, shows that preventing AEA breakdown in the body decreased stress-induced anxiety and improved mood in rats. During the study, rats had been exposed to a maze test and foot shock. Low levels of AEA were correlated negatively with fear response, stress, and anxiety. Anandamide uses in mental health may therefore range from relieving stress and anxiety to better response to fear.
⦁ AEA is very useful when it comes to management of pain
Relieving of pain in the body is one of the major anandamide uses. A research published in the year 2013 proposes that this compound regulates inflammation and pain via several channels. These channels are comprised of the TRPV1 and the CB1 cannabinoid receptors. TRPVI receptor assists the body in feeling both pain and heat.
Another study suggested that drugs which prevent the anandamide breakdown may turn out useful in the future in the management of pain. It’s also not surprising that some cannabis components inhibit the AEA degradation.
⦁ Post-exercise relief
The cannabis high and the “runner’s high” may not turn out too different. Though endorphins were regarded as culprits for possibly longest time, some of the smart German researchers in the year 2015 highlighted that actually, endorphins are too big to be able to pass into the brain. Anandamide is instead considered as the molecule for the work.
A research published in PNAS concluded that cannabinoid receptors are very crucial when it comes to runner’s high main aspects. After exercise, Anandamide levels in the blood increases. The molecule then manages to pass via the barrier of the blood brain. It’s also thought that the molecule improves mood and lowers pain after having intense exercise.
⦁ Controlling the feeling of hunger
Another anandamide function is appetite regulation. Anandamide is passed to the babies by their mothers through breast feeding. According to research done on animals, scientists have speculations that anandamide presence enhances suckling in newborns.
Additional study indicated that rodents that took an average amount of anandamide dosage ate more. Rodents also ate less when the researchers blocked anandamide binding locations. Already, a drug associated to diet namely Rimonabant tried to prevent gain of weight through cannabinoid receptors blockage.
1. Market -- The growing demand for AEA
With people becoming more and more aware of the benefits of Anandamide (AEA), the demand for Anandamide (AEA) supplements has increased greatly in the market. This has led to manufacturing companies vying with each other to produce high-quality supplements to grab share in the market. If you are a health supplements manufacturer planning to foray into the
Anandamide supplements market, you must ensure that you are getting the highest-quality Anandamide (AEA) powder. Sourcing good-quality material is the first step in ensuring the success of any business.
If you are looking for a place to buy Anandamide (AEA) powder in bulk, the one company you can blindly trust for sourcing raw material is Cofttek. The company, owing to its strong research team and dedicated sales department, has established a worldwide presence in only a short amount of time — it has clients and partners around the world. The Anandamide (AEA) produced by the company comes in big batches of 25 kgs and is sourced from highest-quality ingredients, thereby ensuring that the supplements produced from it can be trusted for quality and efficacy. If you want to buy Anandamide (AEA) in bulk, the only place to shop is cofttek.com.
Conclusion
The above is the reason why AEA is so popular. If you think that you have anandamide deficiency, it is recommended that you look for ways to boost your anandamide levels. Anandamide for sale is available online in various online supplement stores. If you want a quick
anandamide buy, feel free to order a pure anandamide powder on cofttek.com.
REFERENCES
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